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KMID : 1123920020160020359
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Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 2 p.359 ~ p.364
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Effects of Hwangryunhaedok-tang plus Yukmijihwang-tang add Chogudeung on Blood Pressure and Renal Function in Spontaneously Hypertensive Rats
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Sohn Eun-Jin
Kang Dae-Gill
Lee An-Sook
Kim Bok-Hae
Lee Ho-Sub
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Abstract
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The present study examined the effects of water extract of Hwangruynhaedoktang plus Yukmijihwangtang add Chogudeung (HYC) on the blood pressure and renal function in spontaneously hypertensive rats (SHR). The HYC water extract blocked increase of systolic blood pressure (SBP) in SHR. The urinary volume (UV), sodium (UNaV), potassium (UkV), and chloride (UclV) excretions were significantly increased in SHR administered with high dose of water extract of HYC, but urinary osmolality was not changed. The creatinine clearance (Ccr), which is index of glomerular filtration rate (GFR), was increased by administration of HYC, while solute-free water reabsorption (TcH2O) was not changed. Taken together, these results suggest that the depressor effects of HYC, at least in part, caused by diuretic effect due to increase of glomerular filtration rate.
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KEYWORD
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Hwangruynhaedok-tang(黃連解毒湯), Yukmijihwang-tang(六味地黃湯), Chogudeung(HYC), Spontaneously hypertensive rats (SHR), Renal function, blood pressure
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